EFFECT OF TRIBULUS TERRESTRIS FRUIT AQUEOUS EXTRACT ON HYPERLIPIDAEMIA AND MAINTENANCE OF LIVER ARCHITECTURE IN ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION IN RATS

Abstract

The present study investigates the protective effects of Tribulus terrestris Fruit aqueous Extract (TTFAEt) in myocardially infarcted rats. The oral administration of TTFAEt to rats for 40 days afforded good protection against isoproterenol-induced alterations, like Hyperlipidemia:  the  disorders  of  lipid  metabolism have  been  ranked  as  one  of  the  greatest  risk  factors contributing  to  the  prevalence  and  severity  of atherosclerosis, stroke and coronary heart diseases. Cardiac levels of lipid peroxidation (LPO) as well as the activities of antioxidant enzymes like Superoxide dismutase (SOD), Catalase (CAT), glutathione peroxidase (GPx), Glutathione-S-transferase (GST). Antioxidants can prevent reactive oxygen species-mediated damage and thus may have potential application in the prevention and cure of such diseases. Myocardial infarction produces a significant abnormal liver functioning. Liver tissue marker enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH). The protective effect of TTFAEt was further supported by the reversal of isoproterenol-induced histological changes in the liver. The results suggest that TTFAEt protect the heart and circulatory system and also hepatoprotective and thereby maintain the near normal architecture of liver tissue.