EFFECT OF MANGIFERA INDICA LEAVES EXTRACT ON ALLOXAN INDUCED DIABETIC MICE

Abstract

The aim of the present study was to investigate the effects of Mangifera indica leaves extract on the kidney function parameters in alloxan induced diabetic Swiss albino mice. Forty five albino mice (weighing 28 to 32 g) were randomly divided into control, alloxan treated and Mangifera indica treated mice group. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at dose of 150 mg/kg body weight. Ethanolic extracts of Mangifera indica leaves at dose of 80 mg/kg body weight were given orally in diabetic mice daily for four weeks after established LD₅₀ value. Results and discussion: In diabetic mice, serum urea, uric acid, creatinine and glucose levels were significantly increased but level of serum albumin was decreased in comparison with the control group. Diabetic mice group, treated with ethanolic extract of Mangifera indica leaves (80 mg/kg b.w), on comparison with diabetic group showed a significant decrease in these biochemical parameters such as urea, uric acid creatinine and glucose level. However, the serum albumin level got increased as compared to diabetic mice. The results suggested that ethanolic extract of Mangifera indica leaves possesses protective effect against alloxan induced diabetic mice.