PURIFICATION OF NON TOXIC ACIDIC PHOSPHOLIPASE A2 FROM INDIAN COBRA (NAJA NAJA) VENOM

Authors

  • DAYANANDA.K.S Department of Studies in Biochemistry, Manasagangothri, Mysore University.
  • VISHWANATH B.S Department of Studies in Biochemistry, Manasagangothri, Mysore University.
  • SHARATH B.K Department of Studies in Biochemistry, Manasagangothri, Mysore University.
  • GOPINATH S.M Department of Biotechnology, Acharya Institute of Technology,Bangalore

Keywords:

Acidic phospholipase A2,Hemolytic activity, Edema, Myotoxicity, LD50, Anticoagulant activity.

Abstract

Acidic phospholipase A2 (NND-IV-PLA2) was isolated from NajaNaja(Southern India) venom, was purified by anion and cation exchange chromatography. The acidic PLA2 profile of eastern and southern region venom is distinctly different from that of the western regional venom, Southern regional acidic phospholipase A2 did not inducemyotoxicity or anticoagulant activity and didn’t induced edema. However, the acidic PLA2 from all the regions follow the pattern of increasing catalytic activity with increase in the acidic nature of the PLA2 isoforms.

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Published

31.03.2013

How to Cite

DAYANANDA.K.S, VISHWANATH B.S, SHARATH B.K, & GOPINATH S.M. (2013). PURIFICATION OF NON TOXIC ACIDIC PHOSPHOLIPASE A2 FROM INDIAN COBRA (NAJA NAJA) VENOM. International Journal of Pharma and Bio Sciences, 4(1), 408–415. Retrieved from https://ijpbs.net/index.php/journal/article/view/2042

Issue

Volume 4, Issue 1, 2013

Section

Research Articles

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