ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF ROOT OF Mukia maderaspatana (L.) ROEMER

Abstract

Peptic ulcer disease (PUD) is a serious gastrointestinal disorder that requires a well targeted therapeutic strategy. So many number of drugs including H2 receptor, antacid and proton pump inhibitors are available for the treatment of peptic ulcer, but clinical evaluation of all these drugs has shown incidence of relapses and side effects. This has been the rationale for the development of new antiulcer drugs and the search for novel molecules has been extended to herbal drugs that offer better protection and decreased relapse. Plant drugs are gaining popularity and are being investigated for various of disorders, including peptic ulcer. Even there are so many herbal remedies for ulcer. The present investigation reviews the antiulcer property of ethanolic extract of root of Mukia maderaspatana in ethanol induced ulcer models in wistar rats. The parameter determined was Gastric volume, Ulcer score, pH, Na+, K+, Free acidity, Total acidity, Pepsin, Total protein, Total carbohydrates and Carbohydrate protein ratio. Ethanolic extract of root of M. maderaspatana at doses of 100, 200, 300mg/kg (body weight) produced dose dependent inhibition of the gastric lesions induced by ethanol. The extract (300 mg/kg) showed significant (P<0.01) gastroprotectivity activity, which was compared with the standard drug Ranitidin (150 mg/kg).