RISK PREDICTION - APOLIPOPROTIENS IN CORONARY ARTERY DISEASE

Abstract

Coronary artery disease (CAD) is a major cause of morbidity and mortality in modern society. Known risk factors for coronary artery disease include dyslipidemia, hypertension, obesity, dysglycemia, insulin resistance, inflammation, arterial intimal thickening, development of vulnerable plaque and thrombosis. This study compared lipid parameters in CAD patients with healthy individuals to see the predictive power of lipid parameters. Results show that a significant number of CAD patients have abnormal lipid profile. LDL-Cholesterol and Apo-B were significantly higher in CAD patients compared to healthy controls. HDL-Cholesterol and Apo A-1 were significantly decreased in CAD patients. The ratio of Apo B/Apo A-1 is highly significant in CAD patients. To conclude Apo A-1 and Apo-B are better predictors of  CAD risk in general, and Apo- B/Apo A-1 ratio seems to be a more powerful predictor of CAD risk than individual apolipoprotein and it can be measured routinely along with lipid profile in the screening of CAD risk.