PROTECTIVE EFFECT OF EMBLICA OFFICINALIS ON CHLORPYRIFOS(AN ORGANOPHOSPHATE INSECTICIDE) INDUCED MALE REPRODUCTIVE SYSTEM IN RATS.

Abstract

Chlorpyrifos is one of the mostly used organophosphates insecticides, has a major toxic effect in mammalian rat’s reproductive system. The ancient Indian herbal formulation, Emblica offcinalis plays a major role to subvert many diseases in human body. Through a preliminary study, we have tried to establish the ameliorative properties of Emblica offcinalis with respect to reproductive rejuvenation in case of Rattus norvegicus, (Wistar Strain). Adult male albino rats were exposed in 7mg/kg/day chlorpyrifos, 20mg/kg/d amla, 7mg chlorpyrifos with 20mg amla/kg/d body weight for 30 days. The Present study indicates that chlorpyrifos provoked an alteration of body weight, male reproductive organs weight and sperm related parameters. These changes are potentially detrimental and lead to infertility in rats. However, when the subjects were treated with amla and chlorpyrifos, these parameters tend to be normalized, thus highlighting the debilitating effect of chlorpyrifos and remedial effect of Emblica officinalis.