MICRODETERMINATION OF SILDENAFIL, TADALAFIL AND VARDENAFIL DRUGS EMPLOYED IN THE ERECTILE DYSFUNCTION THERAPY IN PHARMACEUTICAL FORMULATIONS AND URINE SAMPLES OF DIABETIC PATIENTS TYPE-II IN TAIF AREA, SAUDIA ARABIA USING ATOMIC EMISSION AND ATOMIC ABSORP

Authors

  • SABRY KH. MOHAMED Medical Laboratories Department, College of Applied Medical Sciences, Taif University, Taif 21944, P. O. Box 2425, KSA.Chemistry Department, Faculty of Science, Fayoum University, Fayoum, Egypt.
  • NAGLAA M. SHALABY Medical Laboratories Department, College of Applied Medical Sciences, Taif University, Taif 21944, P. O. Box 2425, KSA.Parasitology Department , Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Keywords:

Atomic emission, atomic absorption, ion-associate complexes, pharmaceutical analysis.

Abstract

Ion – associate complexes of sildenafil, tadalafil and vardenafil  hydrochlorides  with [ Manganese(II) and Cobalt(II)] thiocyanates, potassium ferricyanide, sodium cobaltinitrite and ammonium reineckate were precipitated and the excess unreacted metal complex was determined. A new method using atomic emission and atomic absorption spectrometry for the determination of the above drugs in pure solutions, in pharmaceutical preparations and urine of diabetic patients type 2 was  given. The drugs can be determined by the affort method in the ranges 0.56 - 104.28, 0.64 - 117.81 and 0.63 – 115.39 μg mL-1 solutions of Sd, Td and Vd, respectively.

Downloads

Published

31.03.2013

How to Cite

SABRY KH. MOHAMED, & NAGLAA M. SHALABY. (2013). MICRODETERMINATION OF SILDENAFIL, TADALAFIL AND VARDENAFIL DRUGS EMPLOYED IN THE ERECTILE DYSFUNCTION THERAPY IN PHARMACEUTICAL FORMULATIONS AND URINE SAMPLES OF DIABETIC PATIENTS TYPE-II IN TAIF AREA, SAUDIA ARABIA USING ATOMIC EMISSION AND ATOMIC ABSORP. International Journal of Pharma and Bio Sciences, 4(1), 1037–1046. Retrieved from https://ijpbs.net/index.php/journal/article/view/1992

Issue

Volume 4, Issue 1, 2013

Section

Research Articles

Categories