PHOTOCHEMISTRY OF PHOTODYNAMIC BIOLOGICAL ACTION OF PHOTOSENSITIZING DRUG TOLAZAMIDE

Authors

  • ANAMIKA GUPTA Department of Chemistry, Aligarh Muslim University, Aligarh. 202002 (U.P.) India
  • WASEEM AHMAD Department of Chemistry, Aligarh Muslim University, Aligarh. 202002 (U.P.) India
  • MOHD. REHAN ZAHEER Department of Chemistry, Aligarh Muslim University, Aligarh. 202002 (U.P.) India
  • JAWAID IQBAL Department of Chemistry, Aligarh Muslim University, Aligarh. 202002 (U.P.) India

Keywords:

Tolazamide, Benzene sulfonamide, Photodegradation, Phototoxicity.

Abstract

Irradiation of sulfonamide derived oral antidiabetic drug, tolazamide (N-[(azepan-1-ylamino) carbonyl]-4-methylbenzenesulfonamide, 1) in a phosphate buffered solution under aerobic atmosphere afforded two photoproducts by cleavage of S-N and C (O)-N bonds of urea units. When irradiated with linoleic acid it photoinduced lipid peroxidation. The insignificant decrease in lipid peroxidation test under argon atmosphere indicates that tolazamide is capable of photosensitizing lipids through a process where oxygen does not play a principal role. Also the efficient inhibition of lipid peroxidation by well established radical scavenger reduced glutathione (GSH) confirmed the involvement of a type I mechanism.

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Published

31.03.2013

How to Cite

ANAMIKA GUPTA, WASEEM AHMAD, MOHD. REHAN ZAHEER, & JAWAID IQBAL. (2013). PHOTOCHEMISTRY OF PHOTODYNAMIC BIOLOGICAL ACTION OF PHOTOSENSITIZING DRUG TOLAZAMIDE. International Journal of Pharma and Bio Sciences, 4(1), 840–846. Retrieved from https://ijpbs.net/index.php/journal/article/view/1969

Issue

Volume 4, Issue 1, 2013

Section

Research Articles

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