EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF KODI PAVALA CHUNNAM IN CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN RATS

Abstract

The Kodi Pavala Chunnam (KPC) is traditionally used in Siddha system. The present investigation was evaluated the hepatoprotective activity KPC against carbon tetrachloride (CCl₄) induced liver damage in wistar rats. The KPC was used 100 mg/kg and 200 mg/kg administered orally to the animals. The Silymarin (100 mg/kg) was given as reference standard. The KPC was effective in protecting the liver against the injury as there was significant produced action in wet liver weight, Liver volume, Direct and total bilirubin, SGPT, SGOT, ALP, Total protein, Cholesterol, Triglyceride, CAT, SOD, LPO.