ANTIULCER ACTIVITY OF POLYHERBAL FORMULATION

Abstract

The lesion of peptic ulcer disease is a disruption in the mucosal layer of the stomach or duodenum. Recent researchers have discovered a number of newer risk factors regulating the development of disease which are not addressed properly by the current clinical therapies. In this study polyherbal formulation was prepared consisting of Glycyrrhiza glabra, Garcinia cambogia, deglycyrrhizinated licorice extract and Azadirachta indica. Suitable extracts depending on effective chemical composition was prepared and studied on four antiulcer models, namely Naproxen induced ulcers, Histamine induced ulcers, Cysteamine induced ulcers and Ethanol induced ulcer models. This polyherbal formulation significantly reduces ulcer index and ulcer area and shows protection index around 80%, the formulation also shows good antioxidant activity. All results show that polyherbal formulation show gastric healing property by multiple mechanisms. These entire drugs target specific etiological and pathological step which take part in development of ulcers.