DESIGN AND IN VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF METOCLOPROMIDE

Abstract

An attempt has been made to develop and evaluate Orally Disintegrating or Mouth Dissolving tablets of Metoclopromide for quick effect, better patient compliance and effective therapy. Fast dissolving tablets of Metoclopromide were prepared by direct compression technique using selected superdisintegrants. The FTIR spectra revealed that, there was no interaction of drug with formulation ingredients. The prepared tablets were evaluated for drug content, friability, hardness, In vitro disintegration and In vitro release studies. All the tablets with different super disintegrants showed  better results. However, required disintegration and dissolution behavior of Metoclopromide was achieved for tablets with Crospovidone (20%) as super disintegrant.