A STUDY ON STABILITY AND IN VIVO DRUG RELEASE OF NAPHAZOLINE AND ANTAZOLINE IN SITU GELLING SYSTEMS FOR OCULAR DELIVERY

Abstract

This work describes the stability of the selected in situ solutions  for ophthalmic delivery of naphazoline hydrochloride ( FF17, FF18) and antazoline phosphate ( GG17 and GG18) based on the pH triggered concept using Carbopol 940 and HPMC K4M. The formulations were evaluated for their pH, isotonicity, gelling capacity, rheological characteristics, in vitro drug release , sterility and in vivo studies in New Zealand rabbits’ eyes.  All the formulations showed satisfactory results  at ocular pH environment  that remains  in contact with the eyes for few hours. The formulations were very stable throughout, at room temperature and at 40 °C.  Higher  amount of  both the drugs were retained in the aqueous humour area over 8 hrs following instillation FF17, FF18, GG17& GG18.  Therefore, in situ gelling system can be used to enhance the ocular retention time  thereby increasing ocular bioavailability and reducing the frequency of dosing .