COMPARATIVE STUDIES ON THE ANTICANCER ACTIVITY OF COLCHICINE BY VARIOUS CONTROLLED DRUG DELIVERY MODES

Abstract

Colchicine is a secondary metabolite, originally  extracted from plants of  the genius colchicum it consists of  the dried ripe seeds of Colchicum autumnale Linn., colchicine effectively functions as a  mitotic poison  or spindle inhibitor but the major disadvantage  of the colchicine is  toxicity and non target cell (normal cell)effect. That toxicity and targeted drug delivery can be controlled by carriers Vesicular systems are a novel means of drug delivery that can enhance bioavailability of encapsulated drug and provide therapeutic activity in a controlled manner for a prolonged period of time. This review describes all aspects of controlled drug delivery including their different controlled drug delivery (niosomes, proniosomes, liposomes, ethosomes),different compositions, the various methods of preparation, methods of characterization, cytotoxicity analysis(MTT assay) and comparative controlled drug delivery analysis. The review also provides detailed information of the various types of controlled drugs that provide reduced toxicity.