PARAOXANASE ACTIVITY AND ITS CONCENTRATION IN TYPE2 DIABETES MELLITUS

Authors

  • DR.SK.DEEPTHI DEPARTMENT OF BIOCHEMISTRY, DEPARTMENT PLASTIC SURGERY NARAYANA MEDICAL COLLEGE AND HOSPITAL, NELLORE, A.P
  • DR.G.AMAR RAGHU NARAYAN DEPARTMENT OF BIOCHEMISTRY, DEPARTMENT PLASTIC SURGERY NARAYANA MEDICAL COLLEGE AND HOSPITAL, NELLORE, A.P

Keywords:

Type2 diabetes mellitus (type2DM), Paraoxonase (PON1), Lipid peroxidation, Atherosclerosis. High density Lipoproteins (HDL) , Low density Lipoprotein (LDL)

Abstract

Human serum paraoxonase is a high density lipoprotein (HDL) associated enzyme capable of hydrolyzing diverse substrates from organophosphate toxins to oxidized Phospholipids and possibly in the prevention of LDL lipid peroxidation. We investigated the serum activity and concentration of paraoxonase levels and fasting blood glucose levels in 104 subjects (42 patients with type2diabetes without Complications, 20 patients with type2 diabetes with complications, 42 controls were taken. Patients with type2 diabetes with complications had lower Paraoxonase activity than those without the complications. These results suggest that decreased PON activity in patients with type2 diabetes were involved with diabetic vascular complications

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Published

31.12.2012

How to Cite

DR.SK.DEEPTHI, & DR.G.AMAR RAGHU NARAYAN. (2012). PARAOXANASE ACTIVITY AND ITS CONCENTRATION IN TYPE2 DIABETES MELLITUS. International Journal of Pharma and Bio Sciences, 3(4), 969–973. Retrieved from https://ijpbs.net/index.php/journal/article/view/1853

Issue

Volume 3, Issue 4, 2012

Section

Research Articles

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