OXIDATIVE STRESS, SIALIC ACID AND TOTAL ANTIOXIDANT STATUS IN PATIENTS WITH TYPE2 DIABETES MELLITUS

Authors

  • V.C.RENJU Division of Biochemistry, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai Nagar,Tamil Nadu,India.
  • K.SANTHA Division of Biochemistry, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai Nagar,Tamil Nadu,India.
  • S.SETHUPATHY Division of Biochemistry, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai Nagar,Tamil Nadu,India.

Keywords:

Type2 diabetes mellitus,Oxidative stress, Thiobarbituric acid (TBARS),HOMA-IR.

Abstract

Oxidative stress plays a major role in the pathogenesis of diabetic mellitus. The present study was undertaken to assess lipid peroxidation by TBARS, antioxidant status using FRAP and inflammatory status using sialic acid in patients with Type2 Diabetes mellitus and healthy individuals in rural population. AnthropometricBiochemical, Fasting insulin, HOMA-IR were estimated in both groups. We observed a positive correlation among FBS,TBARS and Sialic acid and they are negatively correlated with FRAP. In this study, we observed that increased blood glucose may play a role in the pathogenesis of oxidative stress which could have lead to reduction of the total antioxidant power.

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Published

31.12.2012

How to Cite

V.C.RENJU, K.SANTHA, & S.SETHUPATHY. (2012). OXIDATIVE STRESS, SIALIC ACID AND TOTAL ANTIOXIDANT STATUS IN PATIENTS WITH TYPE2 DIABETES MELLITUS. International Journal of Pharma and Bio Sciences, 3(4), 789–795. Retrieved from https://ijpbs.net/index.php/journal/article/view/1833

Issue

Volume 3, Issue 4, 2012

Section

Research Articles

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