NEUROPHARMACOLOGICAL STUDIES OF DREVOGENINS ISOLATED FROM WATTAKAKA VOLUBILIS (LINN.F.) STAPF. IN MICE

Authors

  • RAM S. JADHAV Department of Biochemistry, Gulbarga University, Gulbarga, Karnataka, India
  • MD. LIYAKAT AHMED Department of Pharmacology, Luqman College of Pharmacy, Gulbarga, Karnataka, India
  • PARAMJYOTHI SWAMY Department of Biochemistry, Gulbarga University, Gulbarga, Karnataka, India
  • SYED SANAULLAH Department of Pharmacology, Luqman College of Pharmacy, Gulbarga, Karnataka, India

Keywords:

Wattakaka volubilis, Drevogenins, motor performance evaluation, muscle relaxant test, neurosteroids

Abstract

The Wattakaka volubilis ethanolic extract (WVEE), Wattakaka volubilis sapogenin mixture (WVSM) and drevogenins (DVG) isolated from Wattakaka volubilis (Linn.f) Stapf. were evaluated for neuropharmacological activities using spontaneous motor activity, rotarod performance, motor performance evolution and muscle relaxant test models in mice. Sapogenins seemed to be responsible for neuropharmacological activities in the studied models. When compared to the saline treated control WVEE at a dose level of 200 mg/kg, WVSM at a dose level of 50 mg/kg and DVG I and II at a dose level of 20 mg/kg body weight significantly increased (p<0.001***) the gross behavioral effect such as gripping strength, muscle tone and muscle coordination.

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Published

31.12.2012

How to Cite

RAM S. JADHAV, MD. LIYAKAT AHMED, PARAMJYOTHI SWAMY, & SYED SANAULLAH. (2012). NEUROPHARMACOLOGICAL STUDIES OF DREVOGENINS ISOLATED FROM WATTAKAKA VOLUBILIS (LINN.F.) STAPF. IN MICE. International Journal of Pharma and Bio Sciences, 3(4), 80–88. Retrieved from https://ijpbs.net/index.php/journal/article/view/1656

Issue

Volume 3, Issue 4, 2012

Section

Research Articles

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