Clinical And Cytogenetic Analysis Of Pervasive Developmental Disorder (Pdd), Mental Retardation (Mr) And Broad Autism Phenotype (Bap) From South Indian Population

Authors

  • S.RAJIV Division of Biomolecules and Genetics, School of Biosciences and Technology, VIT University, Vellore, Tamilnadu, India,
  • V.G.ABILASH Division of Biomolecules and Genetics, School of Biosciences and Technology, VIT University, Vellore, Tamilnadu, India,
  • M.PAPAKUMARI Dr. Rama Rau Polyclinic, Kilpauk, Chennai, Tamilnadu, India
  • M.MURUGAN Dr. Rama Rau Polyclinic, Kilpauk, Chennai, Tamilnadu, India

Keywords:

Pervasive Developmental Disorder (PDD), Broad Autism phenotype (BAP), Mental Retardation (MR), Autism, Chromosomal Aberration.

Abstract

The aim of study is to analyze the clinical and cytogenetic investigation on patients with PDD, MR and BAP from South Indian population. Cytogenetic analysis of 11 patients with PDD, 3 patients with BAP and 12 patients with MR were carried out by using human leukocyte culturing method and clinical analysis were carried out for all the cases with the help of physicians. A significantly higher number of chromosomal aberrations were observed in all groups when compared to the controls (p < 0.001). This study shows the significantly higher number of chromosomal aberrations in all the cases through karyotyping and chromosomal aberration analysis, which has to be further investigated deeply to detect the possible genetic causes of autism to provide genetic counseling, awareness and management of autistic children.

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Published

30.09.2012

How to Cite

S.RAJIV, V.G.ABILASH, M.PAPAKUMARI, & M.MURUGAN. (2012). Clinical And Cytogenetic Analysis Of Pervasive Developmental Disorder (Pdd), Mental Retardation (Mr) And Broad Autism Phenotype (Bap) From South Indian Population. International Journal of Pharma and Bio Sciences, 3(3), 531–544. Retrieved from https://ijpbs.net/index.php/journal/article/view/1584

Issue

Volume 3, Issue 3, 2012

Section

Research Articles

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