Clinical Analysis, Drug Designing And QSAR Studies On Rheumatoid Arthritis

Authors

  • D.S.V.G.K.KALADHAR Department of Bioinformatics,GIS, GITAM University, Visakhapatnam-530045, India.
  • K.V.V.V.SATYANARAYANA Department of Chemistry, GIS, GITAM University, Visakhapatnam-530045, India.
  • A. KRISHNA CHAITANYA Department of Bioinformatics,GIS, GITAM University, Visakhapatnam-530045, India.
  • S. A. K. ZAKIR HUSSAIN Department of Bioinformatics,GIS, GITAM University, Visakhapatnam-530045, India.

Keywords:

Rheumatoid Arthritis, QSAR.

Abstract

The clinical data related to Rheumatoid Arthritis has shown that there is more number of males (60%) than females (40%) during January month at KGH, Visakhapatnam, India. The patients also have more number of Neutrophils (72%) and Lymphocytes (18%) and less number of Eosinophils (10%) and Monocytes (0%) suffering from Rheumatoid Arthritis. Based on docking results Leflunomide and Desoxycorticosterone Pivalate shown good results based on distance approach (43.5) against RA. Based on Emin values, Auranofin (-66.73) has shown good activity compared with other selected drugs. Based on QSAR analysis Cyclosporine and Phenacetin are related and also shown similar results with docking. 

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Published

31.12.2010

How to Cite

D.S.V.G.K.KALADHAR, K.V.V.V.SATYANARAYANA, A. KRISHNA CHAITANYA, & S. A. K. ZAKIR HUSSAIN. (2010). Clinical Analysis, Drug Designing And QSAR Studies On Rheumatoid Arthritis. International Journal of Pharma and Bio Sciences, 1(4), 132–138. Retrieved from https://ijpbs.net/index.php/journal/article/view/158

Issue

Volume 1, Issue 4, 2010

Section

Research Articles