SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL SCHIFF BASES ANALOGUE OF 3-(4-AMINO) PHENYLIMINO) 5- FLUOROINDOLIN-2-ONE.

Authors

  • NIRMAL.R Balaji Institute of Pharmacy, Laknepally(V),Narsampet(M), Warangal, Andhra Pradesh – 506 331
  • AJAY BABU.CH M.A.M college of Pharmacy, Kesanupalli (V), Narsaraopet, Guntur(D), Andhra Pradesh– 522 601, India.
  • PRASAD RAO. M M.A.M college of Pharmacy, Kesanupalli (V), Narsaraopet, Guntur(D), Andhra Pradesh– 522 601, India.

Keywords:

Schiff base, 3-(4-Amino) Phenylimino) 5- substituted indolin-2-One , Anitmicrobial study

Abstract

The synthesis and the in vitro evaluation of antibacterial activity of new schiff bases analogues of 3-(4-Amino) Phenylimino) 5- substituted indolin-2-One are reported. The newly synthesized compounds were characterized by IR, 1H NMR and Mass spectral studies. Representative compounds were screened for antibacterial (Staphylococcus aureus ATCC-9144, Staphylococcus epidermidis ATCC-155, Micrococcus luteus ATCC-4698, Bacillus cereus ATCC-11778, Escherichia coli ATCC-25922, Pseudomonas aeruginosa ATCC-2853, and Klebsiella pneumoniae ATCC-11298) and antifungal (Aspergillus niger ATCC-9029 and Aspergillus fumigatus ATCC-46645) activities by paper disc diffusion technique. The minimum inhibitory concentrations (MICs) of the compounds were also determined by agar streak dilution method. 

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Published

30.09.2010

How to Cite

NIRMAL.R, AJAY BABU.CH, & PRASAD RAO. M. (2010). SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL SCHIFF BASES ANALOGUE OF 3-(4-AMINO) PHENYLIMINO) 5- FLUOROINDOLIN-2-ONE. International Journal of Pharma and Bio Sciences, 1(3), 1–8. Retrieved from https://ijpbs.net/index.php/journal/article/view/157

Issue

Volume 1, Issue 3, 2010

Section

Research Articles