Anti-Diabetic And Anti-Arthritic Potential Of Glycosmis Pentaphylla Stem Bark In Fca Induced Arthritis And Streptozotocin Induced Diabetic Rats

Abstract

The anti-diabetic and anti-arthritic potential of the ethonolic extract of stem bark of Glycosmis pentaphylla (Rutaceae), a medicinal plant widely used in the traditional Ayurveda and siddha systems of medicine for the treatment by the streptozotocin induced diabetic model and anti-arthritic activity was evaluated by FCA induced arthritis for separate group of animals. Graded doses of the ethonolic extract of Glycosmis pentaphylla were administered to experimental arthriticand diabetic rats (different groups) for 21days.Significant (p≤0.01) reductions in fasting blood glucose levels and inflammation were observed in the respective diabetic and arthritic animals. Increase in Serum insulin levels was observed in diabetic animals due to pancreatic β cell regeneration. There is a significant improvement of the haematological parameters like RBC count, Hb level  and  the  ESR  to  a  near  normal  level indicating the  significant  recovery from the anaemic condition and arthritic progress thus justifying its significant role in arthritic conditions. In this study we are focusing the same plant derivatives of Glycosmis pentaphylla was used for reducing the complications of diabetes and arthritis in rats.