Rp-Hplc Method For Quantitative Estimation Of Olanzapine In Tablet Dosage Forms

Authors

  • A.RUKMANGADA RAO Department of pharmaceutical Analysis, Nimra College of pharmacy, IbrahimpatnamNimra College of Pharmacy, Nimra nagar, Ibrahimpatnam, Vijayawada-521456, Andhra Pradesh, India
  • N.DELHI RAJ Department of pharmaceutical Analysis, Nimra College of pharmacy, Ibrahimpatnam Nimra College of Pharmacy, Nimra nagar, Ibrahimpatnam, Vijayawada-521456, Andhra Pradesh, India
  • JAGADEESH Department of pharmaceutical Analysis, Nimra College of pharmacy, Ibrahimpatnam Nimra College of Pharmacy, Nimra nagar, Ibrahimpatnam, Vijayawada-521456, Andhra Pradesh, India

Keywords:

Olanzapine, Estimation, RP-HPLC, Validation, Tablets.

Abstract

A simple RP-HPLC method for the determination of olanzapine in pharmaceutical dosage forms. Numerous HPLC conditions were tested for determination of olanzapine. The best result was achieved by using Capcell pak C-18 (250×4.6mm) 5µm column and a mobile phase consisting of Acetonitrile: Water: Tri ethylamine (60:40:0.1 v/v/v), a flow rate of 1.0 ml/min with ultraviolet detection at 270nm. The retention time of the drug was 6.53 min. The method produced liner responses in the concentration range of 2 to 12µg/ml of olanzapine. The method was found to be applicable for determination of the drug in tablets.

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Published

30.09.2012

How to Cite

A.RUKMANGADA RAO, N.DELHI RAJ, & JAGADEESH. (2012). Rp-Hplc Method For Quantitative Estimation Of Olanzapine In Tablet Dosage Forms. International Journal of Pharma and Bio Sciences, 3(3), 267–272. Retrieved from https://ijpbs.net/index.php/journal/article/view/1482

Issue

Volume 3, Issue 3, 2012

Section

Research Articles

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