Effect Of Solanum Torvum On The Contractile Response Of Isolated Tissues Preparation In Fructose Fed Rat

Abstract

The present study was aimed to determine the effect of ethanolic extract of Solanum torvum (100 and 300 mg/kg; p.o. for 6 weeks) on isolated strip of ascending colon, Fundus and Vasdeferens in fructose (10%) fed rat. Chronic administration of S. torvum extract (100, 300 mg/kg/day, p.o.) in fructose fed rats significantly (p<0.05) shifted the CCRC of  Angiotensin (Ang-II, 10 ng/ml) and  5-Hydroxytryptamine (5-HT, 10 µg/ml) to the right with suppression of maxima as compared to CCRC of fructose fed rats on isolated ascending colon and fundus strip respectively. CCRC of Phenylephrine (PE, 10 µg/ml) using isolated Vas deferens was significantly (p<0.05) rise in rats cotreated with S. torvum (100, 300 mg/kg/day, p.o.). The results clearly suggest that S. torvum could block the Ang-II and 5-HT receptor and it also activate α₁-adrenergic pathway in this in-vitro model study.