Synthesis Of Novelthiazoles Containing Pyrazolone Systems And Antimicrobial Acivity

Authors

  • L.K.RAVINDRANATH Department of chemistry, S.K.University Anantapur, Andrapradesh, India.
  • E.V.SURESH KUMAR Department of chemistry, S.K.University Anantapur, Andrapradesh, India.
  • K.SRIKANTH Y.N.SPOORTHI Department of chemistry, S.K.University Anantapur, Andrapradesh, India.
  • P.PHEBE Department of chemistry, S.K.University Anantapur, Andrapradesh, India.

Keywords:

Thiazole derivatives, Pyrazolones derivatives, microwave irradiation, antimicrobial activity

Abstract

Several thiazoles and pyrazolone carrying heterocyclic nucleus were synthesized and tested as antimicrobial agents. All compounds and some of the nitro substituted derivatives have effective antibacterial properties against Gram positive bacteria (Staphylococcus aureus NCCS 2079 and Bacillus cereus NCCS 2106), Gram negative bacteria (Escherichia coli NCCS 265 and Pseudomonas aeruginosa NCCS2200). The antifungal activity of synthesized compounds were studied by disc diffusion method against the organisms of Aspergillus niger NCCS 1196 and Candida albicans NCCS 3471. The chemical structures of these newly synthesized compounds were characterized by 1H-NMR, Mass, and IR spectral data.

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Published

30.09.2012

How to Cite

L.K.RAVINDRANATH, E.V.SURESH KUMAR, K.SRIKANTH Y.N.SPOORTHI, & P.PHEBE. (2012). Synthesis Of Novelthiazoles Containing Pyrazolone Systems And Antimicrobial Acivity. International Journal of Pharma and Bio Sciences, 3(3), 52–59. Retrieved from https://ijpbs.net/index.php/journal/article/view/1456

Issue

Volume 3, Issue 3, 2012

Section

Research Articles

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