Armats Biotech Private Ltd., Chennai 600 085

Abstract

Thyroid hormones influences the metabolism of all the substrates including minerals.   A patient with thyroid dysfunction may also manifests the symptoms that are consequent upon the altered mineral levels. The study shows that  hyper thyroidism increases the Ca⁺⁺ level decreased by bone turn over.  In hyperthyroidism increased tubular re absorption of Po₄^- affecting GFR, low clearance of Po₄-.  Hyperthyroidism decreased renal blood flow will be leading to low clearance of Mg²⁺ & Zn⁺ from kidney.  So low tubular excretion of Mg²⁺ & Zn⁺ will be prominent at plasma levels. The study was conducted over a period of six months.  In this study, 30 subjects hyperthyroidism with euthyroidism were selected. Both males and females were included.  Blood samples were collected  for estimation of TSH, FT3,FT4, serum Ca, serum Po₄^-, serum Mg²⁺ & serum Zn⁺. In Hyperthyroid patients, the serum levels of minerals Ca⁺, Zn⁺, Mg²⁺   (p<0.001) were significantly increased and PO₄  (p<0.001) levels were significantly decreased compared to controls. Mineral status  is observed in all the patients Ca⁺ levels are high  because decreases bone turnover  abating  phosphorus levels negative   influences on paratharmone and calcitonine, Zn⁺ & Mg²⁺ levels reflects the influences on GFR and increased clearance of these minerals