Spectrophotometric Method Developed For The Estimation Of Flucloxacilin In Bulk And Dosage Form Using UV-VIS Spectrophotometric Method

Authors

  • SUDDHASATTYA DEY Guru Nanak Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Dist-Ranga Reddy, Andhra Pradesh, India.
  • RATNAKAR CH. Guru Nanak Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Dist-Ranga Reddy, Andhra Pradesh, India.
  • S. VAITHIYANATHAN Guru Nanak Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Dist-Ranga Reddy, Andhra Pradesh, India.
  • HIMANSU BHUSAN SAMAL Guru Nanak Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Dist-Ranga Reddy, Andhra Pradesh, India.
  • Y.VIKRAM REDDY Guru Nanak Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Dist-Ranga Reddy, Andhra Pradesh, India.
  • BALA KRISHNA Guru Nanak Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Dist-Ranga Reddy, Andhra Pradesh, India.
  • Y. ANIL REDDY Guru Nanak Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Dist-Ranga Reddy, Andhra Pradesh, India.
  • G. NAVIN KUMAR Guru Nanak Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Dist-Ranga Reddy, Andhra Pradesh, India.
  • SUBHASIS MOHAPATRA Greater Hyderabad Institute of Pharmacy, Ibrahimpatnam, Hyderabad-501506, Dist-Ranga Reddy, Andhra Pradesh, India.

Keywords:

FLUCLOXACILLIN, λmax, ICH, UV-VIS spectroscopy, Beta-lactam antibiotic.

Abstract

The present study describes a simple, accurate, precise and cost effective UV-VIS Spectrophotometric method for the estimation of FLUCLOXACILLIN, is a penicillin beta-lactam antibiotic, in bulk and pharmaceutical dosage form. The solvent used was double distilled water and the λmax or the absorption maxima of the drug was found to be 219nm. A linear response was observed in the range of 2-10µg/ml with a regression coefficient of 0.998. The method was then validated for different parameters as per the ICH 2(International Conference for Harmonization) guidelines.  This method can be used for the determination of FLUCLOXACILLIN in quality control of formulation without interference of the excipients. 

Downloads

Published

31.12.2010

How to Cite

SUDDHASATTYA DEY, RATNAKAR CH., S. VAITHIYANATHAN, HIMANSU BHUSAN SAMAL, Y.VIKRAM REDDY, BALA KRISHNA, … SUBHASIS MOHAPATRA. (2010). Spectrophotometric Method Developed For The Estimation Of Flucloxacilin In Bulk And Dosage Form Using UV-VIS Spectrophotometric Method. International Journal of Pharma and Bio Sciences, 1(4), 35–43. Retrieved from https://ijpbs.net/index.php/journal/article/view/135

Issue

Volume 1, Issue 4, 2010

Section

Research Articles