Effect Of Flumethrin On Tissue Biochemistry Following Oral Administration In Wistar Albino Rats

Authors

  • AKHILESH MISHRA PhD Fellow, Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences, Mohanpur campus, Nadia-741235, West Bengal, India.
  • GAYATRI DEWANGAN Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences, Mohanpur campus, Nadia-741235, West Bengal, India.
  • VIKAS MAHAJAN Division of animal Breeding & Genetics, SKUAST – J (J&K), F.V.SC & A.H
  • T K MANDAL 1Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences, Mohanpur campus, Nadia-741235, West Bengal, India.

Keywords:

Flumethrin; oxidative stress; superoxide dismutase; lipid peroxidation; aspartate transaminase; alanine transaminase

Abstract

The effect of daily oral administration of flumethrin on the tissue enzyme activity on albino rats was investigated. In the present study twenty albino Wister rats were used and divided into two groups. The first group (10 rats) served as the control group; the second group (10 rats) both male and female received flumethrin (1% pour on formulation) at the rate of 5 mg/kg bw orally daily for 14 days. On day 15, animals were sacrificed and liver tissue samples were collected. Flumethrin leads to increased MDA, ALT, AST levels and decreased catalase, SOD and protein level. The present study suggests that flumethrin is having hepato-toxic effect, producing oxidative stress in animal’s body.  

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Published

30.06.2012

How to Cite

AKHILESH MISHRA, GAYATRI DEWANGAN, VIKAS MAHAJAN, & T K MANDAL. (2012). Effect Of Flumethrin On Tissue Biochemistry Following Oral Administration In Wistar Albino Rats. International Journal of Pharma and Bio Sciences, 3(2), 191–200. Retrieved from https://ijpbs.net/index.php/journal/article/view/1324

Issue

Volume 3, Issue 2, 2012

Section

Research Articles

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