A Simple Extractive Spectrophotometricdetermination Of Loratadine, Desloratadine And Rupatadine From Pharmaceutical Formulations

Abstract

Simple sensitive and accurate extractive spectrophotometric method was developed for the estimation of loratadine, desloratadine and rupatadine in pharmaceutical dosage forms. The method was based on the formation of colored ion pair complexes by the drugs with thiocynate ions. These ion pair complexes were quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 618 nm,614 nm  and 616 nm respectively. The proposed method was validated statistically.Recoveries of method was carried out by standard addition methods. The Beer’s lawranges were found to be 1-12 μg/ml, 0.5-3 μg/ml and 0.5-8 μg/ml for  loratadine, desloratadine and rupatadine  respectively. The low values of standard deviation and percentage RSDindicate high precision of method. Hence the method is useful for routine estimation of loratadine, desloratadine and rupatadine in tablets respectively.Loratadine,Desloratadine,Rupatadine fumarate ,Cobalt nitrate,Ammonium thiocynate,Chloroform