Comparative Wound Healing Activity Of Different Leaf Extracts Of Lantana Camara Linn.

Abstract

Lantana camara Linn. is a heavily branched shrub that can grow in compact clumps, dense thickets or as a climbing vine. and has covered large areas in India, Australia. and much of Africa. In order to evaluate the wound healing activity of Lantana camara L., two different solvent extracts were prepared from the leaves of the plant. Ethyl acetate and Ethanol were used for the extraction of the active ingredients. Excision wound model on Wistar albino rats of 4 months, of both sexes, weighing between 100 to 150 gm was used to assess the wound healing activity of the leaves. Remarkable wound healing activity was observed with the ointment formulation of the ethanol extract at 2% concentration. Wound contraction was calculated as percentage of the reduction in wound area. A specimen sample of tissue was isolated from the healed skin of each group of mice for the histopathological examination, the results of which also supported the outcome of excision wound models. The present study demonstrated that the aerial parts of Lantana  camara  L. promote wound healing activity in mice as a preclinical study.