Anti Diarrhoeal Activity Of Ziziphus Jujuba Leaf Extract In Rats

Abstract

The plant Ziziphus jujuba(  Rhamnaceae ),   is a small ever green and possesses a number of medicinal properties. The purpose of the present study was to evaluate the anti diarrhoeal activity of the aqueous extract of the leaves of Ziziphus jujuba, by using castor oil and MgSo4 (Magnesium sulphate) induced diarrhea model. The aqueous extract of leaves of this plant at graded doses was investigated for anti -diarrhoeal activity in terms of reduction in the rate of defaecation and consistency of faeces in Castor oil, Mgso4 induced diarrhea.  Effect was further evaluated on gastrointestinal transit time with charcoal meal. The leaves extract showed significant inhibitory activity against castor oil and Mgso4 induced diarrhea. There was significant reduction in gastro intestinal motility by the charcoal meal test in rats.  The results obtained by this study substantiate the anti diarrhoeal effects of the aqueous extract.