Pharmacological Aspects Of Tapentadol

Abstract

Tapentadol  is a centrally acting FDA approved analgesic for the treatment of moderate to severe acute pain with a dual mode of action as an agonist at the μ-opioid receptor and as a nor epinephrine reuptake inhibitor.  It is used in chronic pain like, post operative, Neuropathic pain and End- stage degenerative joint disease. Oral dosages of 50 mg, 75 mg, or 100 mg /six hours tablets are available. Common side effects nausea, vomiting, dizziness, somnolence, headache, decreased seizure thresh hold, fatigue and also has dependence liability.