Serum Superoxide Dismutase And Paraoxonase-1 Activity In Preeclampsia Patients

Authors

  • ANIL B. BARGALE Department of Biochemistry, SDMCMSH, Dharwad, Karnataka, India.
  • JAYASHREE V. GANU Department of Biochemistry, GMC, Miraj, Maharashtra, India.
  • DHIRAJ J. TRIVEDI Department of Biochemistry, SDMCMSH, Dharwad, Karnataka, India
  • PRAMOD S. KAMBLE Department of Biochemistry, SDMCMSH, Dharwad, Karnataka, India
  • RAKESH MUDARADDI Department of Biochemistry, SDMCMSH, Dharwad, Karnataka, India

Keywords:

Preeclampsia, Endothelial cell dysfunction, Superoxide Dismutase, Paraoxonase-1

Abstract

Preeclampsia (PE) is a multisystem disorder characterized by hypertension, proteinuria and edema. Endothelial cell (EC) injury plays an important role in the pathogenesis of PE. The antioxidant enzyme SOD is a scavenger of superoxide anion and prevents oxidative damage of EC. Dysfunction of EC is associated with dyslipidemia due to oxidation of LDL, which is lowered by the enzyme PON-1. The aim of present study is to determine superoxide dismutase and paraoxonase-1 activity in preeclamptic women. In this study we found that serum SOD and PON-1 activity was decreased in preeclamptic women (3.614±0.539, 45.815±4.725) as compared to normal pregnant women (5.796±1.242, 65.012±6.318). But, SOD and PON-1 activity in between mild and severe PE women’s were not-significant. Our observed results show decrease in the antioxidant SOD and PON-1 activity point towards their role in the pathogenesis of PE.

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Published

31.12.2011

How to Cite

ANIL B. BARGALE, JAYASHREE V. GANU, DHIRAJ J. TRIVEDI, PRAMOD S. KAMBLE, & RAKESH MUDARADDI. (2011). Serum Superoxide Dismutase And Paraoxonase-1 Activity In Preeclampsia Patients. International Journal of Pharma and Bio Sciences, 2(4), 784–789. Retrieved from https://ijpbs.net/index.php/journal/article/view/1146

Issue

Volume 2, Issue 4, 2011

Section

Research Articles

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