Aromatic Antiepileptic Drug Reactions

Abstract

Drug eruptions to aromatic antiepileptics are  on increase . Reactions noticed are protean in nature and early detection is important which needs diligent observation. In our experience we had three cases with three different types of drug reactions to carbamazepine. One case had a morbilliform drug eruption with carbamazepine. We had another case  with diagnosis- DRESS syndrome to Carbamazepine. (DR –delayed reaction, E- eosinophilia SS- systemic signs. The third case was steven johnsons  syndrome. : In all the cases, the offending drug Carbamazepine was stopped immediately. Symptomatic treatment was given and  antiepileptic drug structurally unrelated to carbamazepine was started. All cases responded well.