Synthesis And In Vitro Antitumor Activity Of New Nicotinyl-Rhodanine Derivatives

Authors

  • BODDU ANANDA RAO Organic Chemistry Division-II, Indian Institute of Chemical Technology, Hyderabad -500607
  • RAVINDRA SINGH RAJPOOT National Institute of Pharmaceutical Education and Research (NIPER-Hyderabad), Balanagar, Hyderabad-500037, India
  • V. G. M. NAIDU Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad 500 607, India
  • KOLUPULA SRINIVAS National Institute of Pharmaceutical Education and Research (NIPER-Hyderabad), Balanagar, Hyderabad-500037, India
  • SISTLA RAMAKRISHNA National Institute of Pharmaceutical Education and Research (NIPER-Hyderabad), Balanagar, Hyderabad-500037, India 3 Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad 500 607, India
  • VAIDYA JAYATHIRTHA RAO National Institute of Pharmaceutical Education and Research (NIPER-Hyderabad), Balanagar, Hyderabad-500037, India 3 Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad 500 607, India

Keywords:

Rhodanine Derivatives, Nicotinaldehydes, Synthesis, Antitumor Activity, Structure-Activity Relations.

Abstract

A series of new nicotinyl-rhodanine derivatives were synthesized by condensing various chloronicotinaldehydes with rhodanine and substituted rhodanines. The in vitro antitumor activity for these compounds was screened against MCF-7, A549 and HT29 human cancer cell lines. The results show that compounds 1, 3, 5, 7, 8 and 9 are more potent against MCF-7 cell lines; compounds 9 and 11 are more potent against A549 cell lines; compound 3 is more potent against HT29 cell lines amongst the 14 nicotinyl-rhodanine compounds synthesized. The relationships between structure and antitumor activity were elucidated.

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Published

31.12.2011

How to Cite

BODDU ANANDA RAO, RAVINDRA SINGH RAJPOOT, V. G. M. NAIDU, KOLUPULA SRINIVAS, SISTLA RAMAKRISHNA, & VAIDYA JAYATHIRTHA RAO. (2011). Synthesis And In Vitro Antitumor Activity Of New Nicotinyl-Rhodanine Derivatives. International Journal of Pharma and Bio Sciences, 2(4), 191–202. Retrieved from https://ijpbs.net/index.php/journal/article/view/1012

Issue

Volume 2, Issue 4, 2011

Section

Research Articles

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