Copper(Ii) Salicylaldehyde-N,N-Dibenzylsemicarbazone – A Potential Antitumour Compound

Authors

  • PETER PENG FOO LEE National Institute of Education, Nanyang Technological University, Republic of Singapore.
  • KENNETH K POON National Institute of Education, Nanyang Technological University, Republic of Singapore.

Keywords:

Salicylaldehye semicarbazone, copper(II) complexes, antitumour, in vivo, LD50.

Abstract

From QSAR studies, a series of salicylaldehyde semicarbazones, HOC6H4CH=N‑NHCONR2 (H2R2) and their Cu(II) complexes were synthesized, characterized and investigated for their biological activities previously. Results obtained showed that one of the most active compounds in this series is [Cu(HBnz2)Cl]. Thus, in this study, research was then carried out to investigate the anti-tumour property of this compound. The LD50 of [Cu(HBnz2)Cl] was determined to be at 75 mg/kg. Anti-tumour property was observed when this compound was introduced to tumours of human origin (MOLT-4 on SCID mice) and murine origin (3LL on normal mice).

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Published

31.12.2011

How to Cite

PETER PENG FOO LEE, & KENNETH K POON. (2011). Copper(Ii) Salicylaldehyde-N,N-Dibenzylsemicarbazone – A Potential Antitumour Compound. International Journal of Pharma and Bio Sciences, 2(4), 174–190. Retrieved from https://ijpbs.net/index.php/journal/article/view/1011

Issue

Volume 2, Issue 4, 2011

Section

Research Articles

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