10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 4 2010 (October - December) A series of novel quinazolinone derivatives have been synthesized by the condensation of 2substituted benzoxazine /6, 8-dibromo-2-substituted benzoxazine with p-amino containing compounds. Structures of the newly synthesized compounds have been established on the basis of their melting point, thin layer chromatography, IR and 1H-NMR data. All the newly synthesized quinazolinone derivatives were evaluated for their anti-bacterial activity by disc diffusion method by measuring the zone of inhibition and the results were compared to standard.  Dr. K. Girija,K. Hemalatha Synthesis, Quinazolinone derivatives, Anti-bacterial activity, p-amino compounds 254-259