10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 2 2011 (April - June) lessThan i greaterThan Streptococcus lessThan /i greaterThan  is the leading cause of dental diseases worldwide and is considered to be the most cariogenic of all of the oral bacteria lessThan i greaterThan . lessThan /i greaterThan The total 150 dental plaque sample were collected from Uttranchal dental college and hospital dehradun and different dental clinics of dehradun. Out of 320 isolates recovered prevalence of lessThan i greaterThan Streptococcus sp. lessThan /i greaterThan was 50%. 10 antibiotics were used against the recovered isolates. 80% of the recovered isolates revealed the sensitive activity against amoxicillin (25 mcg), ampicillin (25 mcg), chloramphenicol (30 mcg), erythromycin (30 mcg), clindamycin (30 mcg), tetracycline (30 mcg), penicillin (100 mcg) and resistant activity against metronidazole (30 mcg), ciprofloxacin (25 mcg), and gentamycin (25 mcg). The antibacterial activity of lessThan i greaterThan Punica granatum lessThan /i greaterThan against the recovered isolates was studied by using agar well diffusion method. Out of four different solvents used in the present study 90 % of the recovered isolates showed the maximum zone of inhibition against the methanolic extract of lessThan i greaterThan Punica granatum lessThan /i greaterThan i.e. 25 mm. Archana Devi,V. Singh And A. B. Bhatt Punica granatum, Dental plaque, Dental caries, Antibacterial activity. 504-508