10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 2 2011 (April - June) Indian Medicinal plants contain many antimicrobial agents and properties. Hence, an attempt has been made to find out newer components from the Indian Medicinal plants Natural antimicrobials can be derived from plants, animal tissues, or microorganisms. The shortcomings of the drugs available today, propel the discovery of new pharmacy-therapeutic agents in medicinal plants. To determine the potential and promote the use of herbal medicine, in the present study of aqueous and ethanoloic extract of 5 medicinal plant tested leaves of lessThan i greaterThan Azadirachta indica lessThan /i greaterThan ( lessThan b greaterThan Meliaceae lessThan /b greaterThan ), lessThan i greaterThan Portulaca oleracea lessThan /i greaterThan ( lessThan b greaterThan Portulacaceae lessThan /b greaterThan ) , lessThan i greaterThan Euphorbia hirta lessThan b greaterThan ( lessThan /b greaterThan lessThan /i greaterThan lessThan b greaterThan Euphorbiaceae lessThan i greaterThan ) lessThan /i greaterThan lessThan /b greaterThan , lessThan i greaterThan Gmelina asiatica lessThan /i greaterThan ( lessThan b greaterThan Verbenaceae lessThan /b greaterThan ), lessThan i greaterThan Santalum album lessThan /i greaterThan ( lessThan b greaterThan ( lessThan /b greaterThan lessThan b greaterThan Santalaceae), lessThan /b greaterThan were screened for their anti-microbial activity against seven species of micro organism lessThan i greaterThan Escherichia coli lessThan /i greaterThan , , lessThan i greaterThan Bacillus subtilis lessThan /i greaterThan , ,, lessThan i greaterThan Pseudomonas aeruginosa lessThan /i greaterThan , Salmonella typhimurium , lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan , lessThan i greaterThan Candida albicans lessThan /i greaterThan and lessThan i greaterThan Aspergillus Niger lessThan /i greaterThan . The susceptibility of the microorganisms to the extracts of these plants was compared with each other and with selected antibiotics. The antimicrobial activities of these plants were discussed according to their phytochemical components. S. Bakkiyaraj And S. Pandiyaraj ANTIMICROBIAL ACTIVITY Azadirachta indica, Portulaca oleracea, Euphorbia hirta, Gmelina asiatica 484-491