10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 2 2011 (April - June) FGFs have diverse roles in regulating cell proliferation, migration and differentiation. Their actions are dependent on their ability to bind and activate a family of cell surface receptors with intrinsic protein tyrosine kinase activity. These receptors possess an extracellular cytoplasmic ligand-binding domain that has three immunoglobulin-like (Ig-like) regions, a hydrophobic transmembrane domain, and a discontinuous intracellular tyrosine kinase domain exhibiting a short intervening sequence. FGF-21 also improves the lipoprotein profiles by decreasing LDL-cholesterol and total cholesterol, and increasing HDL cholesterol. FGF-21 transgenic mice exhibit similar metabolic characteristics, namely reduced adiposity and resistance to diet-induced metabolic disturbances. Ashish Kakkar Fibroblast,diabetes,lipoprotein. 469-474