10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 2 2011 (April - June) Diabetes mellitus (DM) is considered a major public health issue because of its increasing prevalence and high morbidity and mortality. Recent research has proposed new targets for fighting against diabetes. The paradox of a well known receptor PPAR γ has been resolved by a scientist and he has proposed a new way to target this receptor. Further other new potential targets have been summarized in order to present a new dimension in the treatment of diabetes mellitus. Sateesh Kumar Dhegavath Diabetes mellitus , pparγ, Target, leptin 461-468