10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 2 2011 (April - June) A rapid and sensitive RP-HPLC method with UV detection (323 nm) for routine analysis of strontium ranelate in bulk and in pharmaceutical formulation as sachet was developed. Chromatography was performed with mobile phase containing a mixture of monobasic potassium phosphate buffer and methanol (3:1 v/v) with the flow rate of 0.8 ml/min at 25 º C. In the range of 50-250 μg/ml, the linearity of strontium ranelate shows a correlation coefficient of 0.999. The percentage recovery studies were found to be in the range of 97-102 %. The proposed method was validated by determining accuracy, precision and ruggedness. The results of all the validation parameters were well within their acceptance values. K. Mythili, S. Gayatri, Koya Ravi Teja, K. Chitra And C. Uma Maheswara Reddy Strontium ranelate, RP- HPLC, UV detection, Validation 258-263