10.22376/ijpbs.2019.10.1.p1-12 Volume 15 Issue 1 January - March The incidence of nausea-vomiting during and immediately after caesarean delivery with spinal anesthesia is a common occurrence andannoying problem to all concerned. The abrupt diaphragmatic contractions present in emesis are uncomfortable to the patient. They may causeprotrusion of the abdominal viscera, rendering surgery more difficult and increasing the risk of visceral injuries. If the stomach is full, aspiration isan additional hazard. Therefore, it is advisable to prevent it during spinal anesthesia for a caesarean section. Our aim of this study is to evaluatethe effectiveness of propofol in controlling nausea and vomiting during cesarean delivery under spinal anesthesia. Our Objective is to assess themagnitude of intraoperative and postoperative nausea, retching, and vomiting in parturients and to evaluate the efficacy of propofol atsubhypnotic doses for reducing emetic episodes in parturients. After getting clearance from the institutional ethical committee, the study wasconducted at S C B Medical College, Cuttack, Odisha, from November 2019 to October 2021 over 2 years. It was a prospective, randomized,double-blind, placebo-controlled study. The result of the study indicates the incidence of intraoperative emetic episodes in caesarean delivery isvery high. In the study, 6% of patients in the propofol group experienced intra-operative vomiting, while in the placebo group, it was30%(p=0.004). Propofol at 1mg/kg/hr infusion, administered immediately after clamping the umbilical cord, significantly decreased the incidenceand severity of nausea, retching, and vomiting and the need for rescue antiemetic therapy compared with placebo. Harekrishna Ray,Tarangini Das, Nupur B Patel, Nibedita Pani and Mangal Charan Murmu Propofol, Nausea, Vomiting, Spinal anesthesia. 42-48