10.22376/ijpbs.2019.10.1.p1-12 Volume 15 Issue 1 January - March Hepatorenal syndrome (HRS) is a multiorgan disease that affects the kidneys and liver. It is a cause of acute kidney injury (AKI) that can be seen in patients suffering from acute or chronic liver disease. The first association of renal failure in cirrhosis was reported during the 1800s. Our study aims to determine the risk factors associated with HRS-AKI in cirrhotic patients to guide clinicians in determining the risk of development of HRS-AKI. Objectives are to know the relation between age, gender, Body Mass Index (BMI), creatinine, Model for End Stage Liver Disease (MELD) scores, history of ascites, ventilation, duration of hospitalization, haemodialysis requirements, presence of any infection, mortality rate with the development of HRS. The study was conducted in the Nephrology Department at a tertiary care centre named NRI. Medical College, Chinakakani, Andhra Pradesh, India, on 100 patients admitted in the nephrology department. Males and females above 18 years, admitted with cirrhosis and AKI, were included in the study. Results showed that among 100 admitted patients, the incidence of HRS was 12%. There was a significant difference in the mean serum creatinine, haemoglobin, and bilirubin levels between cases and controls. The mean duration of hospitalization, death rate, and need for mechanical ventilation were significantly more among cases compared to controls. We conclude that the prevalence of hepatorenal syndrome is high among patients with cirrhosis and AKI. Dr. Moturu Venkata Viswanath, Dr N S Tejaswi Karri, Dr Varaprasada Rao Kaki and Dr Sirisha G Hepatorenal syndrome, Cirrhosis, Acute Renal Failure, Decompensated liver injury, Mortality, Risk factors 54-62