10.22376/ijpbs.2019.10.1.p1-12 Volume 14 Issue 4 October - December Sepsis is a medical emergency that describes the body's systemic immunological response to an infectious process that can lead to end-stage organ dysfunction and death. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis has very high morbidity and mortality, leading to a major healthcare burden worldwide. Though there is far advancement in the therapeutic options, the mortality rate remains high due to the delay in the diagnosis because of the lack of availability of reliable diagnostic methods. This study aimed to observe the utility of Urine Albumin-Creatinine ratio with SAPS II score among patients with sepsis. It is a Hospital based prospective analytical study conducted to study the utility of the correlation of Urine Albumin-Creatinine ratio with SAPS II score in patients with sepsis period was July 2021 to November 2022 at General Medicine Department in Tertiary Care Hospital. Institutional Ethics Committee approved the study. It was observed that most patients were male 34 (56.67%) and female 26 (43.33%). It was observed that most patients were in the age group 41-50 years 14 (23.33%) followed by 51-60 years 12 (20%); the mean age of the patients was 45.1 ± 17.15 years. This study concludes that the Urine Albumin-Creatinine ratio with SAPS II score is useful in sepsis diagnosis. The urinary ACR estimation is an easy, cheap, and non-invasive tool and may be used to identify high-risk sepsis cases in resource settings. Dr. D.P. Lakra, Dr. M. Khande and Dr. Sujay Trivedi (SAPS II), Urine Albumin-Creatinine Ratio (ACR), SIRS, Serum Creatinine, Sepsis. 7-12