10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 2 2011 (April - June) The objective of present study was to develop and evaluate dosage form containing floating micro balloons of indapamide, in combination with immediate release minitablet of telmisartan, for treatment of hypertension. Microballoons of indapamide were prepared using Emulsion solvent diffusion technique. These were evaluated for entrapment efficiency, particle size, particle shape using scanning electron microscopy technique, percentage buoyancy and lessThan i greaterThan invitro lessThan /i greaterThan release. The formulations were optimized using 2 lessThan sup greaterThan 3 lessThan /sup greaterThan factorial design. Telmisartan minitablets were prepared using direct compression method and were evaluated for parameters like weight variation, hardness, friability, disintegration time and lessThan i greaterThan invitro lessThan /i greaterThan release. Micoballoons and minitablets were filled in a hard gelatin capsule. Capsules were evaluated for lessThan i greaterThan invitro lessThan /i greaterThan drug release studies using High performance liquid chromatography technique. Telmisartan was released immediately within 20 minutes while indapamide was released over 24 hours following Higuchi model. Synergistic effect was confirmed by animal studies. Blood Pressure in animal models was measured using Tail Cuff Method. Neha M. Munot And Amrita N. Bajaj Indapamide, Telmisartan, micro balloons, solvent evaporation, tail cuff method. 141-152