10.22376/ijpbs.2019.10.1.p1-12 Volume 13 Issue 3 July-September Fluoride water problem is very common in all areas of world including India. The deleterious effects of fluoride on bones causes fluorosis. This problem arises mainly due to gradual lowering of ground water level, which is merely responsible for degrading water quality. The hand pumps of many areas are restricted for use due to excess fluoride in their water. In a country like India, it is very tough to provide pure drinking water to all. Hence this study is designed to study the effect of fluoride on biochemical parameters in albino rats, the mammalian model. The aim and objective of this study is to evaluate combination of two antioxidants viz. lessThan i greaterThan Tamarindus indica lessThan /i greaterThan (rich source of vitamin C) and vitamin D against fluoride toxicity in mammals for which albino rat is used as model. Tamarindus have significant amount of antioxidants and vitamin D also have immunity and healing properties, hence this can be a reason behind their cumulative ameliorative effect against sodium fluoride intoxication. Further, the effect of fluoride can be minimized or ameliorated using some antioxidants and vitamins. For this purpose, the fluoride intoxicated rats were observed for possible amelioration by lessThan i greaterThan Tamarindus indica lessThan /i greaterThan and vitamin D supplementation. The fluoride intoxication showed altered biochemical parameters like serum protein, SGOT, SGPT, ACP, ALP and LDH Shalini Yadav P.K. Singh, Prem Sagar and Harendra Nath Sharma Fluoride, Tamarindus Indica, Vitamin D, Serum Glutamic-Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase, Acid Phosphatase, Alkaline Phosphatase, Lactate Dehydrogenase. 57-63