10.22376/ijpbs.2019.10.1.p1-12 Volume 12 issue 4 October - December lessThan i greaterThan Physalis lessThan /i greaterThan is a genus of a perennial, herbaceous or annual plant, which is mostly the local plant of tropical North & South America. Few species of lessThan i greaterThan Physalis lessThan /i greaterThan are widely distributed in warmer parts of world. Some species of lessThan i greaterThan Physalis lessThan /i greaterThan grow in its edible fruits. One or two species occur wildly in India, while three other species are cultivated. Plant lessThan i greaterThan Physalis peruviana lessThan /i greaterThan Linn. (Family: Solanaceae) is one of the important species of genus lessThan i greaterThan Physalis lessThan /i greaterThan found in India, especially leaves & fruits have been traditionally used as a diuretic, muscle relaxant, in inflammation, for prevention of tooth decay & abdominal ailments throughout the world. The plant is reported to relieve hypertension, asthma, urinary problem & widely valued for its calming properties. The present study was initiated to investigate the diuretic effect of hydroalcoholic extract of lessThan i greaterThan Physalis peruviana lessThan /i greaterThan (HEPP) in Wistar rats. Hydroalcoholic extract of lessThan i greaterThan Physalis peruviana lessThan /i greaterThan leaves was administered at the dose of 50, 100 & 200 mg/kg,p.o. Hydrochlorothiazide (500mg/kg, p.o.) was used as a positive control in the study. The diuretic effect of the extract was evaluated by measuring the volume of urine, sodium, chloride & potassium content in the urine sample. Urine volume significantly increased at two doses of HEPP extract that is 100 & 200 mg/kg body weight in treated rats. Excretion of chloride, sodium and potassium levels were also increased (77.42 mmol/l, 85.20 mmol/l and 43.6 mmol/l respectively) by HEPP extract (200 ml/kg).The diuretic effect of the hydroalcoholic extract was similar to hydrochlorothiazide at the dose of 200 ml/kg. This study concluded that HEPP produced a notable diuretic effect which appeared to be comparable to that produced by the standard diuretic hydrochlorothiazide. The present study provides a quantitative basis for investigating the use of lessThan i greaterThan Physalis peruviana lessThan /i greaterThan as a diuretic agent. Dr. Kundan Singh Bora and Pooja Shah Physalis, Physalis peruviana, Diuretic Activity, Lipschitz Test, Therapeutic Activity, Hydroalcoholic. 1-7