10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 3 2010 (July - September) It is crucial to determine the safety profile of components used in food or pharma products. lessThan i greaterThan Acacia Nilotica lessThan /i greaterThan exudate gum (ANG) and lessThan i greaterThan Soymida febrifuga lessThan /i greaterThan exudate gum (SFG) have shown similar acacia gum properties, but their safety profile is not studied. In the present study, acute oral toxicity of lessThan i greaterThan ANG lessThan /i greaterThan and lessThan i greaterThan SFG lessThan /i greaterThan was investigated in female Sprague-Dawley rats for 14 days. The study aims to investigate the lessThan i greaterThan ANG lessThan /i greaterThan and lessThan i greaterThan SFG lessThan /i greaterThan exudate gums safety in terms of adverse reactions and mortality. Bodyweight and hematological parameters were monitored from zero-day in the interval of 2 and 7 days, respectively. This showed no significant reduction in lessThan i greaterThan ANG lessThan /i greaterThan and lessThan i greaterThan SFG lessThan /i greaterThan fed groups' body weight compared to the control group. Also, hematological parameters in the animal fed with lessThan i greaterThan ANG lessThan /i greaterThan and lessThan i greaterThan SFG showed no considerable change lessThan /i greaterThan compared to the control group. The significant increase in ALT and AST in the liver homogenate following the administration of 2000 mg/kg aqueous lessThan i greaterThan ANG lessThan /i greaterThan because of the enzyme induction by the high dose of the exudate gums synthesizes the increased enzymes. The histopathological study showed no significant changes in the liver and other organ sections of animals fed with ANG and SFG compared to the control group. The LD lessThan sub greaterThan 50 lessThan /sub greaterThan of lessThan i greaterThan SFG lessThan /i greaterThan and lessThan i greaterThan ANG lessThan /i greaterThan were found to be more than 2000 mg/kg, and it suggested that these gum exudates were safe for food and pharmaceutical applications. Pravin R. Bhushette, Satish V. Rojekar and Uday S. Annapure Exudate Gum Toxicity, Haematological study; Histopathological study; Acacia Nilotica; Soymida febrifuga 58-69