International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 12 Issue 3
2021 (July-September)
Hematological Parameters and Biochemical Evaluation of the Effects of Vitamin C in Swiss Albino Mice Exposed to Chronic Doses of Cadmium
Cadmium toxicity characterizes a global environmental contamination delinquent and a common source of industrial and non-occupational neurological diseases. Cadmium toxicity is common among heavy metal toxicity even at minimum exposure because of slow excretion rate from the body and long biological half-life. The purpose of the present study was to determine the role of vitamin C against cadmium-induced toxicity in Swiss albino mice. This current study was performed by the biochemical parameters and hematological analysis in Swiss albino mice as affected by the oral administration of a single dose equivalent to 1/20 from LD lessThan sub greaterThan 50 lessThan /sub greaterThan (100 mg/kg B.W.) of Cadmium individually for 35 days and evaluated the protective role of vitamin C. The results presented a significant reduction (P lessThan 0.05) in White Blood Cells count (W.B.C.s) and Red Blood Cell (R.B.C.s) count in Cadmium-treated animals in comparison with the control group. The results from other studies showed a significant reduction of the body weight of cadmium treated mice and were compared with the control group. While total serum protein and total cholesterol significantly decreased (P lessThan 0.05) in cadmium-treated animals compared with the control group. Biochemical parameters showed a significant increase (P lessThan 0.05) in urea and creatinine levels in cadmium treated mice when compared to the control group. Vitamin C is recognized an essential nutrients for all species of animals. In other words, these vitamins have been shown to have protective effect against heavy metal induced toxicity. In conclusion, this study demonstrates that oral exposure of cadmium caused reduction in biochemical and hematology activities in mice and vitamin C has ameliorative effect against metal-induced toxicity. Vitamin C is a natural antioxidant that prevents the increased production of free radicals induced by oxidative damage to lipid and lipoproteins in numerous tissues and cellular compartments
Priyanka Dadupanthi, Shilpa Bhargava
Cadmium, Toxicity, Protective, Vitamin C, Antioxidant agent
33-41