10.22376/ijpbs.2019.10.1.p1-12 Volume 11 Issue 3 2020 (July-September) Hypertension is a major health problem which affects about 30% of all adults worldwide. Angiotensin-I converting enzyme (ACE) plays a vital role in the regulation of blood pressure and helps in conversion of angiotensin I into angiotensin II. Inhibiting the ACE activity could reduce blood pressure. As ACE inhibitory drugs can cause adverse side effects, hence, there is a need for the identification of new drugs from natural sources. India has a very long, safe and continuous usage of many herbal drugs and several Indian medicinal plants remains unexplored. Thus, the present study focuses on identifying potent ACE inhibitory compounds from 5 Indian medicinal plants by using AutoDock. We have used AutoDock is used to predict the interaction between macromolecules (protein) with small molecules (ligands) at molecular level. The binding energies of the compounds were compared with the standard drugs Temocapril, Lisinopril, Enalapril and Captopril and the natural compounds showing higher binding energy. The plants selected for the study are lessThan i greaterThan Aegle marmelos lessThan /i greaterThan , lessThan i greaterThan Euphorbia hirta lessThan /i greaterThan , lessThan i greaterThan Senna auriculata lessThan /i greaterThan , lessThan i greaterThan Ocimum tenuiflorum lessThan /i greaterThan and lessThan i greaterThan Hibiscus rosa sinensis lessThan /i greaterThan . Total of 32 phytochemical compounds were identified from the KNApSAck database. From the analysis, three significant compounds β-amyrin (-10.6Kcal/mol), Taraxerol (-9.94Kcal/mol) and Lupenol (-10.17Kcal/mol) showed ACE higher inhibition activity than the standard drugs Captopril (-4.4Kcal/mol), Enalapril (-6.47Kcal/mol), Lisinopril (-8.68Kcal/mol) and Temocapril (-8.68Kcal/mol) were identified. All the 3 selected compounds showed interactions on the binding sites of the ACE. The identified compounds can be used for further research as potential drugs with higher inhibition and lesser side effects can be developed as alternatives to synthetic drugs. Sanjay Prasad S and Dr. Shanthi priya. S Hypertension, Angiotensin-I converting enzyme, Medicinal plants, AutoDock, Phytochemical compounds 79-85