10.22376/ijpbs.2019.10.1.p1-12 Volume 11 Issue 2 2020 (April-June) Central Nervous System (CNS) neoplasms are a mix of a wide variety of tumors and include both benign and malignant tumors. They constitute approximately 2% of all malignancies. The present study was a five year retrospective study from a single cancer center in Kerala., India. The aim of the study was to assess the clinicopathologic spectrum of CNS tumors. All cases diagnosed as CNS tumors, primary and metastatic from 2013 January to December 2017 were included in the study. Archival data of 99 cases was considered. All cases were diagnosed by histopathological and immunohistochemistry (when required) examination based on WHO classification. A total of 99 cases of CNS tumors were studied. The average age of patient ranged from 13 years to 72 years. There were 54 male and 45 female patients and the male to female ratio was 1.2:1. Most of the cases- 65.5% -were seen in the 41 to 70 year age groups. Headache was the most common presenting complaint seen in 45.4% of patients. 95% were intracranial and 5% were of spinal location. Most common intracranial site was the frontal lobe 29.7%. Right sided tumors predominated. There were 69.6% glial tumours and 30.3% nonglial tumours. Histologically glioblastomas predominated (36.1%), followed by astrocytomas (21.2%), meningiomas (14.8%) and oligodendrogliomas (7.3%). There were six cases of metastatic carcinomas. Good radiologic histologic correlation was seen in 88 cases. CSF involvement was seen in 2% cases. A total of 19.1% cases recurred of which predominant type was glioblastoma (7 cases). Primary CNS tumors encompass a wide spectrum of benign to malignant tumors with varying grades and can affect all age groups. Histopathological diagnosis is essential for further management after neurosurgery. Rate of recurrence is seen to increase with increase in grade of tumours. Brain is also a favoured site of metastasis especially in primary lung and breast carcinomas. DR. SUNITHA GATTIGORLA, DR. SITHARA ARAVIND, DR. SANGEETHA K NAYANAR AND DR. ARUN NARENDRAN CNS tumors, Clinicopathologic pattern of CNS tumors, Glioblastoma, Astrocytomas, Meningiomas 30-37